All Articles

2024

  • Rona, G., Miwatani-Minter, B., Zhang, Q., Goldberg, H. V., Kerzhnerman, M. A., Howard, J. B., Simoneschi, D., Lane, E., Hobbs, J. W., Sassani, E., Wang, A. A., Keegan, S., Laverty, D. J., Piett, C. G., Pongor, L. S., Xu, M. L., Andrade, J., Thomas, A., Sicinski, P., Askenazi, M., Ueberheide, B., Fenyö, D., Nagel, Z. D. & Pagano, M. CDK-independent role of D-type cyclins in regulating DNA mismatch repair. Mol Cell (2024).

2023

  • Zhang, Q., Kerzhnerman, M. A., García-Vázquez, N., Rona, G. Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle. J. Vis. Exp (2023).

  • Rona, G. & Pagano, M. CDT1, a licensing factor that limits rereplication. Mol Cell 83, 1-3 (2023).

     

  • Pongor, L. S., Schultz, C. W., Rinaldi, L., Wangsa, D., Redon, C. E., Takahashi, N., Fialkoff, G., Desai, P., Zhang, Y., Burkett, S., Hermoni, N., Vilk, N., Gutin, J., Rona, G., Zhao, Y., Nichols, S., Vilimas, R., Sciuto, L., Graham, C., Caravaca, J. M., Turan, S., Shen, T. W., Rajapakse, V. N., Kumar, R., Upadhyay, D., Kumar, S., Kim, Y. S., Roper, N., Tran, B., Hewitt, S. M., Kleiner, D. E., Aladjem, M. I., Friedman, N., Hager, G. L., Pommier, Y., Ried, T. & Thomas, A. Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes. Cancer Discov (2023).

  • Li, J., Krause, G. J., Gui, Q., Kaushik, S., Rona, G., Zhang, Q., Liang, F. X., Dhabaria, A., Anerillas, C., Martindale, J. L., Vasilyev, N., Askenazi, M., Ueberheide, B., Nudler, E., Gorospe, M., Cuervo, A. M. & Pagano, M. A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion. Sci Adv 9, eadh1134 (2023).

  • Chen, X., Lu, Q., Zhou, H., Liu, J., Nadorp, B., Lasry, A., Sun, Z., Lai, B., Rona, G., Zhang, J., Cammer, M., Wang, K., Al-Santli, W., Ciantra, Z., Guo, Q., You, J., Sengupta, D., Boukhris, A., Zhang, H., Liu, C., Cresswell, P., Dahia, P. L. M., Pagano, M., Aifantis, I. & Wang, J. A membrane-associated MHC-I inhibitory axis for cancer immune evasion. Cell 186, 3903-3920 e3921 (2023).

    2022

  • Rona, G., Zeke, A., Miwatani-Minter, B., de Vries, M., Kaur, R., Schinlever, A., Garcia, S. F., Goldberg, H. V., Wang, H., Hinds, T. R., Bailly, F., Zheng, N., Cotelle, P., Desmaele, D., Landau, N. R., Dittmann, M. & Pagano, M. The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target. Cell Death Differ 29, 285-292 (2022).

    2021

  • Simoneschi, D., Rona, G., Zhou, N., Jeong, Y. T., Jiang, S., Milletti, G., Arbini, A. A., O'Sullivan, A., Wang, A. A., Nithikasem, S., Keegan, S., Siu, Y., Cianfanelli, V., Maiani, E., Nazio, F., Cecconi, F., Boccalatte, F., Fenyo, D., Jones, D. R., Busino, L. & Pagano, M. CRL4(AMBRA1) is a master regulator of D-type cyclins. Nature 592, 789-793 (2021).

  • Miwatani-Minter, B. & Rona, G. Laser Micro-Irradiation to Study DNA Recruitment During S Phase. J Vis Exp (2021).  

  • Mena, E. L., Donahue, C. J., Vaites, L. P., Li, J., Rona, G., O'Leary, C., Lignitto, L., Miwatani-Minter, B., Paulo, J. A., Dhabaria, A., Ueberheide, B., Gygi, S. P., Pagano, M., Harper, J. W., Davey, R. A. & Elledge, S. J. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. Proc Natl Acad Sci U S A 118 (2021).

  • Maiani, E., Milletti, G., Nazio, F., Holdgaard, S. G., Bartkova, J., Rizza, S., Cianfanelli, V., Lorente, M., Simoneschi, D., Di Marco, M., D'Acunzo, P., Di Leo, L., Rasmussen, R., Montagna, C., Raciti, M., De Stefanis, C., Gabicagogeascoa, E., Rona, G., Salvador, N., Pupo, E., Merchut-Maya, J. M., Daniel, C. J., Carinci, M., Cesarini, V., O'Sullivan, A., Jeong, Y. T., Bordi, M., Russo, F., Campello, S., Gallo, A., Filomeni, G., Lanzetti, L., Sears, R. C., Hamerlik, P., Bartolazzi, A., Hynds, R. E., Pearce, D. R., Swanton, C., Pagano, M., Velasco, G., Papaleo, E., De Zio, D., Maya-Mendoza, A., Locatelli, F., Bartek, J. & Cecconi, F. AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. Nature 592, 799-803 (2021).

    2020

    Palinkas, H. L., Bekesi, A., Rona, G., Pongor, L., Papp, G., Tihanyi, G., Holub, E., Poti, A., Gemma, C., Ali, S., Morten, M. J., Rothenberg, E., Pagano, M., Szuts, D., Gyorffy, B. & Vertessy, B. G. Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments. Elife 9 (2020).

  • Horvath, A., Rona, G., Pagano, M. & Jordan, P. W. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. BMC Mol Cell Biol 21, 36 (2020).

    2019 

  • Szeder, B., Tarnoki-Zach, J., Lakatos, D., Vas, V., Kudlik, G., Mero, B., Koprivanacz, K., Banyai, L., Hamori, L., Rona, G., Czirok, A., Furedi, A. & Buday, A. L. Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells. Cells 8 (2019).

  • Rona, G. & Pagano, M. Mixed ubiquitin chains regulate DNA repair. Genes Dev 33, 1615-1616 (2019).

  • Palinkas, H. L., Racz, G. A., Gal, Z., Hoffmann, O. I., Tihanyi, G., Rona, G., Gocza, E., Hiripi, L. & Vertessy, B. G. CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. Biomolecules 9 (2019).

    2018

  • Rona, G., Roberti, D., Yin, Y., Pagan, J. K., Homer, H., Sassani, E., Zeke, A., Busino, L., Rothenberg, E. & Pagano, M. PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. Elife 7 (2018).

    2017

  • Lango, T., Rona, G., Hunyadi-Gulyas, E., Turiak, L., Varga, J., Dobson, L., Varady, G., Drahos, L., Vertessy, B. G., Medzihradszky, K. F., Szakacs, G. & Tusnady, G. E. Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins. Sci Rep 7, 42610 (2017).

    2016

  • Rona, G., Scheer, I., Nagy, K., Palinkas, H. L., Tihanyi, G., Borsos, M., Bekesi, A. & Vertessy, B. G. Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications. Nucleic Acids Res 44, e28 (2016).

  • Dankert, J. F., Rona, G., Clijsters, L., Geter, P., Skaar, J. R., Bermudez-Hernandez, K., Sassani, E., Fenyo, D., Ueberheide, B., Schneider, R. & Pagano, M. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Mol Cell 64, 507-519 (2016).

  • Christie, M., Chang, C. W., Rona, G., Smith, K. M., Stewart, A. G., Takeda, A. A., Fontes, M. R., Stewart, M., Vertessy, B. G., Forwood, J. K. & Kobe, B. Structural Biology and Regulation of Protein Import into the Nucleus. J Mol Biol 428, 2060-2090 (2016).

    2015

  • Horvath, A., Batki, J., Henn, L., Lukacsovich, T., Rona, G., Erdelyi, M. & Vertessy, B. G. dUTPase expression correlates with cell division potential in Drosophila melanogaster. FEBS J 282, 1998-2013 (2015).

    2014 

  • Szabo, J. E., Nemeth, V., Papp-Kadar, V., Nyiri, K., Leveles, I., Bendes, A. A., Zagyva, I., Rona, G., Palinkas, H. L., Besztercei, B., Ozohanics, O., Vekey, K., Liliom, K., Toth, J. & Vertessy, B. G. Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control. Nucleic Acids Res 42, 11912-11920 (2014).

  • Rona, G., Palinkas, H. L., Borsos, M., Horvath, A., Scheer, I., Benedek, A., Nagy, G. N., Zagyva, I. & Vertessy, B. G. NLS copy-number variation governs efficiency of nuclear import--case study on dUTPases. FEBS J 281, 5463-5478 (2014).  

  • Rona, G., Borsos, M., Ellis, J. J., Mehdi, A. M., Christie, M., Kornyei, Z., Neubrandt, M., Toth, J., Bozoky, Z., Buday, L., Madarasz, E., Boden, M., Kobe, B. & Vertessy, B. G. Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle 13, 3551-3564 (2014).

    2013

  • Rona, G., Marfori, M., Borsos, M., Scheer, I., Takacs, E., Toth, J., Babos, F., Magyar, A., Erdei, A., Bozoky, Z., Buday, L., Kobe, B. & Vertessy, B. G. Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr D Biol Crystallogr 69, 2495-2505 (2013).

  • Leveles, I., Nemeth, V., Szabo, J. E., Harmat, V., Nyiri, K., Bendes, A. A., Papp-Kadar, V., Zagyva, I., Rona, G., Ozohanics, O., Vekey, K., Toth, J. & Vertessy, B. G. Structure and enzymatic mechanism of a moonlighting dUTPase. Acta Crystallogr D Biol Crystallogr 69, 2298-2308 (2013).

  • Chis, L., Hriscu, M., Bica, A., Tosa, M., Nagy, G., Rona, G., B, G. V. & Dan Irimie, F. Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain. J Gen Appl Microbiol 59, 119-134 (2013).

  • Beke, D., Szekrenyes, Z., Palfi, D., Rona, G., Balogh, I., Maak, P. A., Katona, G., Czigany, Z., Kamaras, K., Rozsa, B., Buday, L., Vertessy, B. & Gali, A. Silicon carbide quantum dots for bioimaging. J Mater Res 28, 205-209 (2013).

    2012

  • Muha, V., Horvath, A., Bekesi, A., Pukancsik, M., Hodoscsek, B., Merenyi, G., Rona, G., Batki, J., Kiss, I., Jankovics, F., Vilmos, P., Erdelyi, M. & Vertessy, B. G. Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. PLoS Genet 8, e1002738 (2012).

    2011

  • Leveles, I., Rona, G., Zagyva, I., Bendes, A., Harmat, V. & Vertessy, B. G. Crystallization and preliminary crystallographic analysis of dUTPase from the phi11 helper phage of Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun 67, 1411-1413 (2011).

  • Bozoky, Z., Rona, G., Klement, E., Medzihradszky, K. F., Merenyi, G., Vertessy, B. G. & Friedrich, P. Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. PLoS One 6, e19546 (2011).

    2008

  • Kiss, R., Bozoky, Z., Kovacs, D., Rona, G., Friedrich, P., Dvortsak, P., Weisemann, R., Tompa, P. & Perczel, A. Calcium-induced tripartite binding of intrinsically disordered calpastatin to its cognate enzyme, calpain. FEBS Lett 582, 2149-2154 (2008).